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Anti-IgG1 Antibody

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Absea Biotechnology
031801A04
Details
Description: Rat monoclonal (KT46) antibody to IgG1
Category: Primary Antibodies
Applications: ELISA, sELISA
Host: Rat
Clonality: Monoclonal
Clone: KT46
Isotype: IgG2a
Conjugate: Unconjugated
UniProt: P01857
Antigen: IgG1
Antigen Species: Human
Sequence: Recombinant human IgG1 Fc.

Target (Information from UniProt)
Function: Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Involvement in Disease: Multiple myeloma: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
Cellular Location: Secreted. Cell membrane.

Product Code - 031801A04
Size Price Quantity
100µg £178
200µg £259
1mg £682

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