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Anti-Kit ligand (SCF) Antibody

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Absea Biotechnology
031117E08
Overview
Name: Anti-Kit ligand (SCF) Antibody
Description: Rat monoclonal (KT118) antibody to Kit ligand (SCF)
Applications: ELISA, sELISA
Antigen: Kit ligand (SCF)
Host: Rat
Clonality: Monoclonal
Clone: KT118
Isotype: IgG2a
Conjugate: Unconjugated

Target (Information from UniProt)
Function: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Involvement in Disease: Hyperpigmentation with or without hypopigmentation, familial progressive: A disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age. Hyperpigmentation has variable intensity, and sometimes is associated with cafe-au-lait macules and larger hypopigmented ash-leaf macules.

Deafness, congenital, unilateral or asymmetric: An autosomal dominant form of non-syndromic, sensorineural deafness characterized by inability to hear affecting one ear. Some patients suffers from asymmetric, bilateral hearing loss.
Sequence Similarities: Belongs to the SCF family.
Post-Translational Modification: A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.
Cellular Location: Cell membrane.
UniProt: P21583
Gene ID: 4254
Synonyms: C Kit Antibody
C kit ligand Antibody
c-Kit Antibody
c-Kit (phospho Y568 + Y570) Antibody
c-Kit (phospho Y703) Antibody
c-Kit (phospho Y721) Antibody
c-Kit (phospho Y730) Antibody
c-Kit (phospho Y823) Antibody
c-Kit (phospho Y936) Antibody
c-Kit Ligand Antibody
CD117 Antibody
Ckit ligand Antibody
DCUA Antibody
DFNA69 Antibody
DKFZp686F2250 Antibody
familial progressive hyperpigmentation 2 Antibody
FPH2 Antibody
FPHH Antibody
Kit Antibody
KIT oncogene Antibody
KIT proto oncogene receptor tyrosine kinase Antibody
Kitl Antibody
KITLG Antibody
KIT_HUMAN Antibody
KL 1 Antibody
KL1 Antibody
Mast cell growth factor Antibody
Mast cell growth factor receptor Antibody
Mast/stem cell growth factor receptor Kit Antibody
MGF Antibody
MGF stem cell factor Antibody
p145 c-kit Antibody
PBT Antibody
Piebald trait protein Antibody
Proto oncogene c Kit Antibody
Proto oncogene tyrosine protein kinase Kit Antibody
Proto-oncogene c-Kit Antibody
SCF Antibody
SCF Receptor Antibody
SCFR Antibody
SCF_HUMAN Antibody
SF Antibody
SHEP7 Antibody
sKITLG Antibody
Soluble KIT ligand Antibody
soluble KIT variant 1 Antibody
Steel factor Antibody
Steel Factor Receptor Antibody
steel, mouse, homolog of Antibody
Stem cell factor Antibody
Stem cell factor precursor Antibody
Stem cell factor receptor Antibody
tyrosine protein kinase Kit Antibody
Tyrosine-protein kinase Kit Antibody
v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog Antibody
v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein Antibody
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Antibody

Product Code - 031117E08
Size Price Quantity
100µg £178
200µg £259
1mg £682

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