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Anti-FANCC Antibody

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ABclonal
A1812
Details
Description: Rabbit polyclonal antibody to FANCC.
Category: Primary Antibodies
Applications: WB, IHC, IF
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q00597
Gene ID: 2176
Immunogen: Recombinant protein of human FANCC
Protein Length: 558
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: FA3; FAC; FACC; FLJ14675
Purification: Affinity purification
Background: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:200

Target (Information from UniProt)
Function: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.
Tissue Specificity: Ubiquitous.
Involvement in Disease: Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Cellular Location: Nucleus. Cytoplasm.

The major form is nuclear. The minor form is cytoplasmic.

Images
Western Blot - Anti-FANCC Antibody from ABclonal (A1812) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using FANCC antibody.
Immunofluorescence - Anti-FANCC Antibody from ABclonal (A1812) - Antibody Supply Service
Immunofluorescence analysis of U2OS cell using FANCC antibody. Blue: DAPI for nuclear staining.

Product Code - A1812
Size Price Quantity
50µl £148
100µl £243
200µl £372

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