|Description:||Rabbit polyclonal antibody to FANCC.|
|Applications:||WB, IHC, IF|
|Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:200|
|Immunogen:||Recombinant protein of human FANCC|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.|
|Involvement in Disease:||Fanconi anemia complementation group C: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.|
|Cellular Location:||Nucleus. Cytoplasm.
The major form is nuclear. The minor form is cytoplasmic.
FA 3 Antibody
Fanconi anemia complementation group C Antibody
Fanconi anemia complementation group C protein Antibody
Fanconi anemia group C protein Antibody
Fanconi pancytopenia type 3 Antibody
Protein FACC Antibody
Western blot analysis of extracts of various cell lines, using FANCC antibody.
Immunofluorescence analysis of U2OS cell using FANCC antibody. Blue: DAPI for nuclear staining.