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Anti-IFNAR1 Antibody

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ABclonal
A1715
Overview
Name: Anti-IFNAR1 Antibody
Description: Rabbit polyclonal antibody to IFNAR1.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human IFNAR1
Protein Length: 557
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
Tissue Specificity: IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.
Sequence Similarities: Belongs to the type II cytokine receptor family.
Post-Translational Modification: Ubiquitinated, leading to its internalization and degradation (PubMed:14532120, PubMed:15337770). Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation (PubMed:18056411). The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex (PubMed:24075985).
Cellular Location: Cell membrane. Late endosome. Lysosome.

Interferon binding triggers internalization of the receptor from the cell membrane into endosomes and then into lysosomes.
UniProt: P17181
Gene ID: 3454
Synonyms: Alpha type antiviral protein Antibody
AVP Antibody
Beta type antiviral protein Antibody
CRF2-1 Antibody
Cytokine receptor class-II member 1 Antibody
Cytokine receptor family 2 member 1 Antibody
IFN alpha R1 Antibody
IFN alpha REC Antibody
IFN alpha receptor Antibody
IFN alpha/beta Receptor alpha Antibody
IFN beta receptor Antibody
IFN-alpha/beta receptor 1 Antibody
IFN-R-1 Antibody
IFNAR Antibody
IFNAR1 (phospho S535 + S539) Antibody
IFNAR1 (phospho Y466) Antibody
IFNBR Antibody
IFRC Antibody
INAR1_HUMAN Antibody
Interferon (alpha beta and omega) receptor 1 Antibody
Interferon alpha receptor 1 Antibody
Interferon alpha/beta receptor 1 Antibody
Interferon alpha/beta receptor alpha chain Antibody
Interferon beta receptor 1 Antibody
Interferon Receptor alpha Antibody
Type I interferon receptor 1 Antibody

Images
Western Blot - Anti-IFNAR1 Antibody from ABclonal (A1715) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using IFNAR1 antibody.

Product Code - A1715
Size Price Quantity
50µl £148
100µl £243
200µl £372

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