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Anti-KIR2DL1 Antibody

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ABclonal
A1697
Details
Description: Rabbit polyclonal antibody to KIR2DL1.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P43626
Gene ID: 3802
Immunogen: Recombinant protein of human KIR2DL1
Protein Length: 348(374)
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: NKAT; NKAT1; p58.1; CD158A; KIR221; KIR-K64
Purification: Affinity purification
Background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200

Target (Information from UniProt)
Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Sequence Similarities: Belongs to the immunoglobulin superfamily.
Cellular Location: Cell membrane.

Images
Western Blot - Anti-KIR2DL1 Antibody from ABclonal (A1697) - Antibody Supply Service
Western blot analysis of extracts of various cells, using KIR2DL1 antibody.

Product Code - A1697
Size Price Quantity
50µl £148
100µl £243
200µl £372

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