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Anti-GNRHR Antibody

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Name: Anti-GNRHR Antibody
Description: Rabbit polyclonal antibody to GNRHR.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic Peptide of human GNRHR
Protein Length: 328
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling.
Tissue Specificity: Pituitary, ovary, testis, breast and prostate but not in liver and spleen.
Involvement in Disease: Hypogonadotropic hypogonadism 7 with or without anosmia: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Sequence Similarities: Belongs to the G-protein coupled receptor 1 family.
Cellular Location: Cell membrane.
UniProt: P30968
Gene ID: 2798
Synonyms: GnRH receptor Antibody
GnRH-R Antibody
GNRHR1 Antibody
Gonadotropin releasing hormone receptor Antibody
gonadotropin-releasing hormone (type 1) receptor 1 Antibody
Gonadotropin-releasing hormone receptor Antibody
GRHR Antibody
HH7 Antibody
leutinizing-releasing hormone receptor Antibody
lh-rh Antibody
LHRHR Antibody
LRHR Antibody
luliberin receptor Antibody
luteinizing hormone releasing hormone receptor Antibody
type I GnRH receptor Antibody

Product Code - A1696
Size Price Quantity
100µl £243
200µl £372

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