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Anti-CD274 Antibody

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ABclonal
A1645
Details
Description: Rabbit polyclonal antibody to CD274.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q9NZQ7
Gene ID: 29126
Immunogen: Recombinant protein of human CD274
Protein Length: 290
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: B7-H; B7H1; MGC142294; MGC142296; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Purification: Affinity purification
Background: Programmed cell death ligand 1(CD274, or B7-H1, PD-L1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
Tissue Specificity: Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.
Sequence Similarities: Belongs to the immunoglobulin superfamily. BTN/MOG family.
Cellular Location: Cell membrane.

Images
Western Blot - Anti-CD274 Antibody from ABclonal (A1645) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using CD274 antibody.

Product Code - A1645
Size Price Quantity
50µl £148
100µl £243
200µl £372

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