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Anti-HSD11B1 Antibody

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ABclonal
A1619
Overview
Name: Anti-HSD11B1 Antibody
Description: Rabbit polyclonal antibody to HSD11B1.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human HSD11B1
Protein Length: 292
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Tissue Specificity: Widely expressed. Highest expression in liver.
Involvement in Disease: Cortisone reductase deficiency: In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Post-Translational Modification: Glycosylated.
Cellular Location: Endoplasmic reticulum membrane.
UniProt: P28845
Gene ID: 3290
Synonyms: 11 beta HSD 1 Antibody
11 beta HSD1 Antibody
11 beta hydroxysteroid dehydrogenase 1 Antibody
11 DH Antibody
11-beta hydroxysteroid dehydrogenase, type 1 Antibody
11-beta-HSD1 Antibody
11-beta-hydroxysteroid dehydrogenase 1 Antibody
11-DH Antibody
11DH Antibody
Corticosteroid 11 beta dehydrogenase isozyme 1 Antibody
Corticosteroid 11-beta-dehydrogenase isozyme 1 Antibody
CORTRD2 Antibody
DHI1_HUMAN Antibody
HDL Antibody
HSD 11 Antibody
HSD11 Antibody
HSD11B Antibody
HSD11L Antibody
Hydroxysteroid (11 beta) dehydrogenase Antibody
Hydroxysteroid (11 beta) dehydrogenase 1 Antibody
MGC13539 Antibody
SDR26C1 Antibody
short chain dehydrogenase/reductase family 26C, member 1 Antibody

Images
Western Blot - Anti-HSD11B1 Antibody from ABclonal (A1619) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using HSD11B1 antibody.

Product Code - A1619
Size Price Quantity
50µl £148
100µl £243
200µl £372

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