|Description:||Rabbit polyclonal antibody to REN.|
|Dilutions:||WB 1:500 - 1:2000|
|Immunogen:||Recombinant protein of human REN|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.|
|Involvement in Disease:||Renal tubular dysgenesis: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Familial juvenile hyperuricemic nephropathy 2: A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
|Sequence Similarities:||Belongs to the peptidase A1 family.|
|Cellular Location:||Secreted. Membrane.
Associated to membranes via binding to ATP6AP2.
|Synonyms:||Angiotensin forming enzyme Antibody
Angiotensin forming enzyme precursor Antibody
Angiotensinogenase precursor Antibody
C 17 orf 36 Antibody
MGC 129844 Antibody
Potassium channel tetramerisation domain containing 11 Antibody
Renin precursor renal Antibody
Retinoic acid EGF NGF induced gene protein Antibody
Western blot analysis of extract of various cells, using REN antibody.