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Anti-REN Antibody

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Description: Rabbit polyclonal antibody to REN.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P00797
Gene ID: 5972
Immunogen: Recombinant protein of human REN
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: FLJ10761
Purification: Affinity purification
Background: Renin is a secreted proteinase whose enzymatic activity is to convert angiotensinogen into angiotensin I in the plasma, initiating a process that results in an elevation of blood pressure and increased sodium retention by the kidney (1). Renin is synthezed in kidney as a procursor, prorenin, which is released into circulation. Both renin and prorenin can bind to (pro)renin receptor and induce angiotensin-independent signaling events leading to activation of MAPKs and up-regulation of TGF-β1 and matrix proteins (2, 3). Defects in renin can cause renal tubular dysgenesis, a severe autosomal recessive disorder of renal tubular development (4, 5).
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
Involvement in Disease: Renal tubular dysgenesis: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

Familial juvenile hyperuricemic nephropathy 2: A renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia.
Sequence Similarities: Belongs to the peptidase A1 family.
Cellular Location: Secreted. Membrane.

Associated to membranes via binding to ATP6AP2.

Western Blot - Anti-REN Antibody from ABclonal (A1585) - Antibody Supply Service
Western blot analysis of extract of various cells, using REN antibody.

Product Code - A1585
Size Price Quantity
50µl £148
100µl £243
200µl £372

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