|Description:||Rabbit polyclonal antibody to IFNB1.|
|Applications:||WB, IHC, IF|
|Immunogen:||Recombinant protein of human IFNB1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonyms:||IFNB1; IFB; IFF; IFNB; MGC96956|
|Background:||The genes encoding type I interferons (IFNs), which include 14 IFN-? genes, one IFN-∫ gene, one IFN-w (also known as IFN-? II1) gene, and a number of IFN-w pseudogenes, are clustered on human chromosome 9. Interferons-? and -∫ are cytokines that are widely known to induce potent antiviral activity. IFN-? and -∫ exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-w is antigenically different from human IFN-?, IFN-∫ or IFN-?, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The type I interferon receptor (IFN-?R) interacts with IFN-?, IFN-∫ and IFN-w, and seems to be a multisubunit receptor.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:200|
Target (Information from UniProt)
|Function:||Has antiviral, antibacterial and anticancer activities.|
|Sequence Similarities:||Belongs to the alpha/beta interferon family.|
Western blot analysis of extracts of various cell lines, using IFNB1 antibody.
Immunohistochemistry of paraffin-embedded human kidney using IFNB1 antibody at dilution of 1:200 (x400 lens)
Immunohistochemistry of paraffin-embedded human esophageal cancer using IFNB1 antibody at dilution of 1:200 (x400 lens)
Immunofluorescence analysis of HepG2 cell using IFNB1 antibody. Blue: DAPI for nuclear staining.