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Anti-IL6R Antibody

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ABclonal
A1570
Details
Description: Rabbit polyclonal antibody to IL6R.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P08887
Gene ID: 3570
Immunogen: Recombinant protein of human IL6R
Protein Length: 468
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: CD126; IL6R-1; IL6R-alpha; IL6RA; MGC104991
Purification: Affinity purification
Background: Interleukin-6 (IL-6) is a pleiotropic cytokine produced by a variety of cells during infection, trauma, and immunological challenge (PMID: 8274730). IL-6 acts via a receptor complex consisting of two distinct membrane-bound glycoproteins, an 80-kDa IL-6-binding subunit (IL6R, CD126, gp80) and a 130-kDa signal-transducing element (gp130, CD130). After binding of IL-6 to membrane-bound IL6R, the complex of IL-6 and IL6R associates with gp130, thus activating the receptor (PMID: 9716487). Expression of gp130 is found in almost all organs while expression of IL6R is predominantly confined to hepatocytes and leukocyte subpopulations (monocytes, neutrophils, T cells, and B cells) (PMID: 11149892). Soluble form of IL6R has been found in human serum and urine.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200

Target (Information from UniProt)
Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Tissue Specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
Sequence Similarities: Belongs to the type I cytokine receptor family. Type 3 subfamily.
Post-Translational Modification: A short soluble form may also be released from the membrane by proteolysis.
Cellular Location: Basolateral cell membrane.

Images
Western Blot - Anti-IL6R Antibody from ABclonal (A1570) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using IL6R antibody.

Product Code - A1570
Size Price Quantity
50µl £148
100µl £243
200µl £372

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