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Anti-SLC16A3 Antibody

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ABclonal
A1554
Details
Description: Rabbit polyclonal antibody to SLC16A3.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: O15427
Gene ID: 9123
Immunogen: A synthetic peptide of human MCT4
Protein Length: 465
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: SLC16A3; MCT4; Monocarboxylate transporter 4
Purification: Affinity purification
Background: Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions (2). However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis (2). In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell (1,2). This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate (1–3).The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm (4). MCT1 is widely expressed and is the major form of MCT in tumor cells and erythrocytes (5,6). MCT2 is highly expressed in liver and testis, while MCT3 and MCT4 are predominantly expressed in skeletal muscle (7,8).
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:200 - 1:500, IHC 1:50 - 1:100

Target (Information from UniProt)
Function: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Tissue Specificity: Highly expressed in skeletal muscle.
Sequence Similarities: Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Cellular Location: Cell membrane.

Images
Western Blot - Anti-SLC16A3 Antibody from ABclonal (A1554) - Antibody Supply Service
Western blot analysis of extracts of various cells,using MCT4 antibody.

Product Code - A1554
Size Price Quantity
100µl £243
200µl £372

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