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Anti-OCN Antibody

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ABclonal
A1530
Details
Description: Rabbit polyclonal antibody to OCN.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P02818
Gene ID: 632
Immunogen: A synthetic peptide of human BGLAP
Protein Length: 100
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: BGLAP; Osteocalcin; Bone Gla protein; Gamma-carboxyglutamic acid-containing protein
Purification: Affinity purification
Background: Bone g-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Genetic variation at the osteocalcin locus on chromosome 1q impacts postmenopause bone mineral density (BMD) levels and may predispose some women to osteoporosis.
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:200 - 1:500, IHC 1:50 - 1:100

Target (Information from UniProt)
Function: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Sequence Similarities: Belongs to the osteocalcin/matrix Gla protein family.
Post-Translational Modification: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
Cellular Location: Secreted.

Images
Western Blot - Anti-OCN Antibody from ABclonal (A1530) - Antibody Supply Service
Western blot analysis of extracts of 293 cell line, using BGLAP antibody.

Product Code - A1530
Size Price Quantity
100µl £243
200µl £372

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