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Anti-Vimentin Antibody

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ABclonal
A1504
Overview
Name: Anti-Vimentin Antibody
Description: Mouse monoclonal antibody to Vimentin.
Applications: WB, IF, IP
Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:200, IP 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant Protein of human VIM
Protein Length: 466
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.
Tissue Specificity: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines.
Involvement in Disease: Cataract 30: An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
Sequence Similarities: Belongs to the intermediate filament family.
Post-Translational Modification: Filament disassembly during mitosis is promoted by phosphorylation at Ser-55 as well as by nestin (By similarity). One of the most prominent phosphoproteins in various cells of mesenchymal origin. Phosphorylation is enhanced during cell division, at which time vimentin filaments are significantly reorganized. Phosphorylation by PKN1 inhibits the formation of filaments. Phosphorylated at Ser-56 by CDK5 during neutrophil secretion in the cytoplasm. Phosphorylated by STK33.
Cellular Location: Cytoplasm.
UniProt: P08670
Gene ID: 7431
Synonyms: CTRCT30 Antibody
Epididymis luminal protein 113 Antibody
FLJ36605 Antibody
HEL113 Antibody
VIM Antibody
Vimentin (phospho S38) Antibody
Vimentin (phospho S50) Antibody
Vimentin (phospho S55) Antibody
Vimentin (phospho S56) Antibody
Vimentin (phospho S71) Antibody
Vimentin (phospho S72) Antibody
Vimentin (phospho S82) Antibody
Vimentin (phospho S83) Antibody
Vimentin (phospho Y38) Antibody
Vimentin (phospho Y61) Antibody
VIME_HUMAN Antibody

Images
Western Blot - Anti-Vimentin Antibody from ABclonal (A1504) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using VIM antibody.

Product Code - A1504
Size Price Quantity
50µl £226
100µl £307
200µl £372

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