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Anti-PLG Antibody

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ABclonal
A1436
Overview
Name: Anti-PLG Antibody
Description: Rabbit polyclonal antibody to PLG.
Applications: WB
Dilutions: WB 1:500 - 1:1000
Reactivity: Human
Immunogen: A synthetic Peptide of human PLG
Protein Length: 810
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.
Tissue Specificity: Present in plasma and many other extracellular fluids. It is synthesized in the liver.
Involvement in Disease: Plasminogen deficiency: A disorder characterized by decreased serum plasminogen activity. Two forms of the disorder are distinguished: type 1 deficiency is additionally characterized by decreased plasminogen antigen levels and clinical symptoms, whereas type 2 deficiency, also known as dysplasminogenemia, is characterized by normal, or slightly reduced antigen levels, and absence of clinical manifestations. Plasminogen deficiency type 1 results in markedly impaired extracellular fibrinolysis and chronic mucosal pseudomembranous lesions due to subepithelial fibrin deposition and inflammation. The most common clinical manifestation of type 1 deficiency is ligneous conjunctivitis in which pseudomembranes formation on the palpebral surfaces of the eye progresses to white, yellow-white, or red thick masses with a wood-like consistency that replace the normal mucosa.
Sequence Similarities: Belongs to the peptidase S1 family. Plasminogen subfamily.
Post-Translational Modification: N-linked glycan contains N-acetyllactosamine and sialic acid. O-linked glycans consist of Gal-GalNAc disaccharide modified with up to 2 sialic acid residues (microheterogeneity).
Cellular Location: Secreted.

Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.
UniProt: P00747
Gene ID: 5340
Synonyms: Angiostatin Antibody
DKFZp779M0222 Antibody
Plasmin Antibody
Plasmin heavy chain A Antibody
Plasmin light chain B Antibody
Plasminogen Antibody
PLMN_HUMAN Antibody

Images
Western Blot - Anti-PLG Antibody from ABclonal (A1436) - Antibody Supply Service
Western blot analysis of extracts of Human blood plasma cells, using PLG antibody.

Product Code - A1436
Size Price Quantity
100µl £243
200µl £372

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