|Description:||Rabbit polyclonal antibody to LIPC.|
|Applications:||WB, IHC, IF|
|Immunogen:||Recombinant protein of human LIPC|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonyms:||HL; HTGL; LIPH; HDLCQ12; LIPC|
|Background:||LIPC, also named as HTGL and HL, belongs to the AB hydrolase superfamily and Lipase family. It has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. LIPC is an important enzyme in HDL metabolism. It binds heparin.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:200|
Target (Information from UniProt)
|Function:||Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.|
|Involvement in Disease:||Hepatic lipase deficiency: A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins.|
|Sequence Similarities:||Belongs to the AB hydrolase superfamily. Lipase family.|
Western blot analysis of extracts of various cell lines, using LIPC antibody.
Immunohistochemistry of paraffin-embedded human colon cancer using LIPC antibody at dilution of 1:200 (x400 lens).
Immunohistochemistry of paraffin-embedded human stomach using LIPC antibody at dilution of 1:200 (x400 lens).
Immunofluorescence analysis of MCF7 cell using LIPC antibody. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of A549 cell using LIPC antibody. Blue: DAPI for nuclear staining.