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Anti-TBP Antibody

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ABclonal
A1423
Overview
Name: Anti-TBP Antibody
Description: Rabbit polyclonal antibody to TBP.
Applications: WB, IHC, IF, FC
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:200, IF 1:20 - 1:50, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human TBP
Protein Length: 339(319)
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (PubMed:2374612, PubMed:2363050, PubMed:2194289, PubMed:9836642, PubMed:27193682). Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III (PubMed:26638071). Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription (PubMed:15970593). The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.
Tissue Specificity: Widely expressed, with levels highest in the testis and ovary.
Involvement in Disease: Spinocerebellar ataxia 17: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA17 is an autosomal dominant cerebellar ataxia (ADCA) characterized by widespread cerebral and cerebellar atrophy, dementia and extrapyramidal signs. The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
Sequence Similarities: Belongs to the TBP family.
Cellular Location: Nucleus.
UniProt: P20226
Gene ID: 6908
Synonyms: GTF2D Antibody
GTF2D1 Antibody
HDL4 Antibody
MGC117320 Antibody
MGC126054 Antibody
MGC126055 Antibody
SCA17 Antibody
TATA binding factor Antibody
TATA binding protein TBP Antibody
TATA box binding protein Antibody
TATA box factor Antibody
TATA sequence binding protein Antibody
TATA sequence-binding protein Antibody
TATA-binding factor Antibody
TATA-box binding protein N-terminal domain Antibody
TATA-box factor Antibody
TATA-box-binding protein Antibody
TBP_HUMAN Antibody
TFIID Antibody
Transcription initiation factor TFIID TBP subunit Antibody

Images
Western Blot - Anti-TBP Antibody from ABclonal (A1423) - Antibody Supply Service
Western blot analysis of Colo320 cell lysate using TBP antibody.

Product Code - A1423
Size Price Quantity
100µl £243
200µl £372

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