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Anti-CYP17A1 Antibody

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ABclonal
A1373
Overview
Name: Anti-CYP17A1 Antibody
Description: Rabbit polyclonal antibody to CYP17A1.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human CYP17A1
Protein Length: 508
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Involvement in Disease: Adrenal hyperplasia 5: A form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH) and 'cryptic' (asymptomatic).
Sequence Similarities: Belongs to the cytochrome P450 family.
Post-Translational Modification: Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.
Cellular Location: Membrane.
UniProt: P05093
Gene ID: 1586
Synonyms: 20 lyase Antibody
CP17A_HUMAN Antibody
CPT7 Antibody
CYP17 Antibody
CYPXVII Antibody
Cytochrome P450 17A1 Antibody
Cytochrome P450 family 17 Antibody
Cytochrome P450 family 17 subfamily A polypeptide 1 Antibody
Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia Antibody
Cytochrome p450 XVIIA1 Antibody
Cytochrome P450-C17 Antibody
Cytochrome P450c17 Antibody
OTTHUMP00000020382 Antibody
P450 C17 Antibody
P450c17 Antibody
S17AH Antibody
Steroid 17 alpha hydroxylase/17,20 lyase Antibody
Steroid 17 alpha monooxygenase Antibody
Steroid 17-alpha-hydroxylase/17 Antibody
Steroid 17-alpha-monooxygenase Antibody

Images
Western Blot - Anti-CYP17A1 Antibody from ABclonal (A1373) - Antibody Supply Service
Western blot analysis of extracts of various cells, using CYP17A1 antibody.

Product Code - A1373
Size Price Quantity
50µl £148
100µl £243
200µl £372

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