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Anti-CYP17A1 Antibody

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ABclonal
A1373
Details
Description: Rabbit polyclonal antibody to CYP17A1.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P05093
Gene ID: 1586
Immunogen: Recombinant protein of human CYP17A1
Protein Length: 508
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: CPT7; CYP17; P450C17; S17AH; CYP17A1
Purification: Affinity purification
Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008]
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200

Target (Information from UniProt)
Function: Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Involvement in Disease: Adrenal hyperplasia 5: A form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH) and 'cryptic' (asymptomatic).
Sequence Similarities: Belongs to the cytochrome P450 family.
Post-Translational Modification: Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.
Cellular Location: Membrane.

Images
Western Blot - Anti-CYP17A1 Antibody from ABclonal (A1373) - Antibody Supply Service
Western blot analysis of extracts of various cells, using CYP17A1 antibody.

Product Code - A1373
Size Price Quantity
50µl £148
100µl £243
200µl £372

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