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Anti-ABCG2 Antibody

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ABclonal
A1370
Details
Description: Rabbit polyclonal antibody to ABCG2.
Category: Primary Antibodies
Applications: WB, IHC, FC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q9UNQ0
Gene ID: 9429
Immunogen: A synthetic Peptide of human ABCG2
Protein Length: 655
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; UAQTL1; EST157481
Purification: Affinity purification
Background: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000, IHC 1:20 - 1:50, FC 1:20 - 1:50

Target (Information from UniProt)
Function: High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
Tissue Specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
Sequence Similarities: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Post-Translational Modification: Glycosylation-deficient ABCG2 is normally expressed and functional.
Cellular Location: Cell membrane. Mitochondrion membrane.

Images
Western Blot - Anti-ABCG2 Antibody from ABclonal (A1370) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using ABCG2 antibody.

Product Code - A1370
Size Price Quantity
100µl £243
200µl £372

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