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Anti-CFH Antibody

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Name: Anti-CFH Antibody
Description: Rabbit polyclonal antibody to CFH.
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human CFH
Protein Length: 1231
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.
Tissue Specificity: Expressed by the liver and secreted in plasma.
Involvement in Disease: Basal laminar drusen: Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early adult-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss.

Complement factor H deficiency: A disorder that can manifest as several different phenotypes, including asymptomatic, recurrent bacterial infections, and renal failure. Laboratory features usually include decreased serum levels of factor H, complement component C3, and a decrease in other terminal complement components, indicating activation of the alternative complement pathway. It is associated with a number of renal diseases with variable clinical presentation and progression, including membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome.

Hemolytic uremic syndrome atypical 1: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease.

Macular degeneration, age-related, 4: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Cellular Location: Secreted.
UniProt: P08603
Gene ID: 3075
Synonyms: adrenomedullin binding protein Antibody
age related maculopathy susceptibility 1 Antibody
AHUS 1 Antibody
AHUS1 Antibody
AMBP 1 Antibody
AMBP1 Antibody
ARMD 4 Antibody
ARMD4 Antibody
ARMS 1 Antibody
ARMS1 Antibody
beta 1 H globulin Antibody
beta 1H Antibody
beta1H Antibody
CFHL 3 Antibody
CFHL3 Antibody
Complement factor H Antibody
complement factor H, isoform b Antibody
Factor H Antibody
factor H like 1 Antibody
FH Antibody
FHL 1 Antibody
FHL1 Antibody
H factor 1 Antibody
H factor 1 (complement) Antibody
H factor 2 (complement) Antibody
HF Antibody
HF 1 Antibody
HF 2 Antibody
HF1 Antibody
HF2 Antibody
HUS Antibody
MGC88246 Antibody

Western Blot - Anti-CFH Antibody from ABclonal (A1360) - Antibody Supply Service
Western blot analysis of extracts of A549 cell line, using CFH antibody.

Product Code - A1360
Size Price Quantity
100µl £243
200µl £372

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