phone icon
+44 (0)1223 298875

Anti-CD14 Antibody

file icon Datasheet
ABclonal
A1347
Overview
Name: Anti-CD14 Antibody
Description: Rabbit polyclonal antibody to CD14.
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human CD14
Protein Length: 375
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187).
Tissue Specificity: Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
Post-Translational Modification: N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Cellular Location: Cell membrane. Secreted. Membrane raft. Golgi apparatus.

Secreted forms may arise by cleavage of the GPI anchor.
UniProt: P08571
Gene ID: 929
Synonyms: CD 14 Antibody
CD14 antigen Antibody
CD14 molecule Antibody
CD14_HUMAN Antibody
CD_antigen=CD14 Antibody
LPS-R Antibody
Mo2 Antibody
Monocyte differentiation antigen CD14 Antibody
Monocyte differentiation antigen CD14 urinary form Antibody
Monocyte differentiation antigen CD14, membrane-bound form Antibody
Myeloid cell specific leucine rich glycoprotein Antibody
Myeloid cell-specific leucine-rich glycoprotein Antibody

Images
Western Blot - Anti-CD14 Antibody from ABclonal (A1347) - Antibody Supply Service
Western blot analysis of extracts of SW480 cell lines, using CD14 antibody.

Product Code - A1347
Size Price Quantity
50µl £243
100µl £372
200µl £565

or
Request a quotation
Contact us directly to order
  • call icon +44 (0)1223 298875
  • +44 (0)1223 281447
  • email icon orders@ab-y-ss.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe