|Description:||Rabbit polyclonal antibody to CYP19A1.|
|Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:100|
|Immunogen:||A synthetic peptide of human CYP19A1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at 4℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Catalyzes the formation of aromatic C18 estrogens from C19 androgens.|
|Tissue Specificity:||Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.|
|Involvement in Disease:||Aromatase excess syndrome: An autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females.
Aromatase deficiency: A rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
|Sequence Similarities:||Belongs to the cytochrome P450 family.|
|Post-Translational Modification:||Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).|
Cytochrome P-450AROM Antibody
Cytochrome P450 19A1 Antibody
Cytochrome P450, family 19, subfamily A, polypeptide 1 Antibody
Cytochrome P450, subfamily XIX (aromatization of androgens) Antibody
Estrogen synthase Antibody
Estrogen synthetase Antibody
Flavoprotein linked monooxygenase Antibody
Microsomal monooxygenase Antibody
P 450AROM Antibody
Western blot analysis of extracts of Jurkat cells, using CYP19A1 antibody.