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Anti-CYP19A1 Antibody

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Name: Anti-CYP19A1 Antibody
Description: Rabbit polyclonal antibody to CYP19A1.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human CYP19A1
Protein Length: 503
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
Tissue Specificity: Widely expressed, including in adult and fetal brain, placenta, skin fibroblasts, adipose tissue and gonads.
Involvement in Disease: Aromatase excess syndrome: An autosomal dominant disorder characterized by increased extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual precocity in females.

Aromatase deficiency: A rare disease in which fetal androgens are not converted into estrogens due to placental aromatase deficiency. Thus, pregnant women exhibit a hirsutism, which spontaneously resolves after post-partum. At birth, female babies present with pseudohermaphroditism due to virilization of extern genital organs. In adult females, manifestations include delay of puberty, breast hypoplasia and primary amenorrhoea with multicystic ovaries.
Sequence Similarities: Belongs to the cytochrome P450 family.
Post-Translational Modification: Phosphorylated in vitro by PKA and PKG/PRKG1. These phosphorylations inhibit the catalytic activity as measured by estrone synthesis from androstenedione (36% decrease for PKA and 30% for PKG/PRKG1).
Cellular Location: Membrane.
UniProt: P11511
Gene ID: 1588
Synonyms: ARO Antibody
ARO1 Antibody
Aromatase Antibody
CP19A_HUMAN Antibody
CPV1 Antibody
CYAR Antibody
CYP19 Antibody
CYPXIX Antibody
Cytochrome P-450AROM Antibody
Cytochrome P450 19A1 Antibody
Cytochrome P450, family 19, subfamily A, polypeptide 1 Antibody
Cytochrome P450, subfamily XIX (aromatization of androgens) Antibody
Estrogen synthase Antibody
Estrogen synthetase Antibody
Flavoprotein linked monooxygenase Antibody
MGC104309 Antibody
Microsomal monooxygenase Antibody
OTTHUMP00000162543 Antibody
OTTHUMP00000198350 Antibody
P 450AROM Antibody

Western Blot - Anti-CYP19A1 Antibody from ABclonal (A1336) - Antibody Supply Service
Western blot analysis of extracts of Jurkat cells, using CYP19A1 antibody.

Product Code - A1336
Size Price Quantity
100µl £243
200µl £372

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