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Anti-ERCC2 Antibody

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ABclonal
A1332
Overview
Name: Anti-ERCC2 Antibody
Description: Rabbit polyclonal antibody to ERCC2.
Applications: WB
Dilutions: WB 1:200 - 1:500
Reactivity: Human
Immunogen: A synthetic peptide of human ERCC2
Protein Length: 760
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
Involvement in Disease: Xeroderma pigmentosum complementation group D: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. Some XP-D patients present features of Cockayne syndrome, including cachectic dwarfism, pigmentary retinopathy, ataxia, decreased nerve conduction velocities. The phenotype combining xeroderma pigmentosum and Cockayne syndrome traits is referred to as XP-CS complex.

Trichothiodystrophy 1, photosensitive: A form of trichothiodystrophy, an autosomal recessive disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD1 patients manifest cutaneous photosensitivity.

Cerebro-oculo-facio-skeletal syndrome 2: A disorder of prenatal onset characterized by microcephaly, congenital cataracts, facial dysmorphism, neurogenic arthrogryposis, growth failure and severe psychomotor retardation. COFS is considered to be part of the nucleotide-excision repair disorders spectrum that include also xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome.
Sequence Similarities: Belongs to the helicase family. RAD3/XPD subfamily.
Post-Translational Modification: ISGylated.
Cellular Location: Nucleus. Cytoplasm > Cytoskeleton > Spindle.
UniProt: P18074
Gene ID: 2068
Synonyms: TFIIH 80 kDa subunit Antibody
Basic transcription factor 2 80 kDa subunit Antibody
BTF2 p80 Antibody
COFS 2 Antibody
COFS2 Antibody
CXPD Antibody
DNA excision repair protein ERCC 2 Antibody
DNA excision repair protein ERCC-2 Antibody
DNA repair protein complementing XP D cells Antibody
DNA repair protein complementing XP-D cells Antibody
EM9 Antibody
ERCC 2 Antibody
ERCC2_HUMAN Antibody
Excision repair 2 Antibody
Excision repair cross complementing rodent repair deficiency complementation Antibody
Excision repair cross complementing rodent repair deficiency, complementation group 2 Antibody
MAG Antibody
MGC102762 Antibody
MGC126218 Antibody
MGC126219 Antibody
OTTHUMP00000045860 Antibody
OTTHUMP00000045861 Antibody
OTTHUMP00000045862 Antibody
OTTHUMP00000045863 Antibody
TFIIH 80 kDa subunit Antibody
TFIIH basal transcription factor complex 80 kDa subunit Antibody
TFIIH Basal Transcription Factor Complex Helicase Subunit Antibody
TFIIH basal transcription factor complex helicase XPD subunit Antibody
TFIIH basal transcription factor complex p80 subunit Antibody
TFIIH p80 Antibody
TTD Antibody
Xeroderma pigmentosum complementary group D Antibody
Xeroderma pigmentosum group D complementing protein Antibody
Xeroderma pigmentosum group D-complementing protein Antibody
XPD Antibody
XPDC Antibody

Images
Western Blot - Anti-ERCC2 Antibody from ABclonal (A1332) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using ERCC2 antibody.

Product Code - A1332
Size Price Quantity
100µl £243
200µl £372

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