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Anti-PAI-1 Antibody

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Name: Anti-PAI-1 Antibody
Description: Rabbit polyclonal antibody to PAI-1.
Applications: WB
Dilutions: WB 1:500 - 1:2000
Reactivity: Human
Immunogen: A synthetic peptide of human SERPINE1
Protein Length: 402
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.
Tissue Specificity: Found in plasma and platelets and in endothelial, hepatoma and fibrosarcoma cells.
Involvement in Disease: Plasminogen activator inhibitor-1 deficiency: A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen.
Sequence Similarities: Belongs to the serpin family.
Post-Translational Modification: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.
Cellular Location: Secreted.
UniProt: P05121
Gene ID: 5054
Synonyms: Clade E Antibody
Endothelial plasminogen activator inhibitor Antibody
Nexin Antibody
PAI Antibody
PAI 1 Antibody
PAI1 Antibody
PAI1_HUMAN Antibody
PLANH1 Antibody
Plasminogen activator inhibitor 1 Antibody
Plasminogen activator inhibitor type 1 Antibody
Serine (or cysteine) proteinase inhibitor Antibody
Serine (or cysteine) proteinase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 Antibody
Serpin E1 Antibody
Serpin peptidase inhibitor clade E Antibody
Serpin peptidase inhibitor clade E (nexin plasminogen activator inhibitor type 1) member 1 Antibody
Serpine 1 Antibody
SERPINE1 Antibody

Western Blot - Anti-PAI-1 Antibody from ABclonal (A1297) - Antibody Supply Service
Western blot analysis of extracts of various cells, using SERPINE1 antibody.

Product Code - A1297
Size Price Quantity
100µl £243
200µl £372

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