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Anti-Kit Ligand (SCF) Antibody (HRP)

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Absea Biotechnology
031101D11H
Details
Description: Rat monoclonal (KT117) antibody to Kit ligand (SCF) (HRP)
Category: Primary Antibodies
Applications: sELISA
Host: Rat
Clonality: Monoclonal
Clone: KT117
Isotype: IgG2b
Conjugate: HRP
UniProt: P21583
Gene ID: 4254
Antigen: Kit ligand (SCF)
Antigen Species: Human
Uniprot Protein Name: Kit ligand
Uniprot Gene Name: KITLG, MGF, SCF

Target (Information from UniProt)
Function: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Involvement in Disease: Hyperpigmentation with or without hypopigmentation, familial progressive: A disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age. Hyperpigmentation has variable intensity, and sometimes is associated with cafe-au-lait macules and larger hypopigmented ash-leaf macules.

Deafness, congenital, unilateral or asymmetric: An autosomal dominant form of non-syndromic, sensorineural deafness characterized by inability to hear affecting one ear. Some patients suffers from asymmetric, bilateral hearing loss.
Sequence Similarities: Belongs to the SCF family.
Post-Translational Modification: A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.
Cellular Location: Cell membrane.

Product Code - 031101D11H
Size Price Quantity
100µg £186
200µg £273
1mg £730

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