Anti-Kit Ligand (SCF) Antibody (HRP)Datasheet
|Description:||Rat monoclonal (KT117) antibody to Kit ligand (SCF) (HRP)|
|Antigen:||Kit ligand (SCF)|
|Uniprot Protein Name:||Kit ligand|
|Uniprot Gene Name:||KITLG, MGF, SCF|
Target (Information from UniProt)
|Function:||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.|
|Involvement in Disease:||Hyperpigmentation with or without hypopigmentation, familial progressive: A disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age. Hyperpigmentation has variable intensity, and sometimes is associated with cafe-au-lait macules and larger hypopigmented ash-leaf macules.
Deafness, congenital, unilateral or asymmetric: An autosomal dominant form of non-syndromic, sensorineural deafness characterized by inability to hear affecting one ear. Some patients suffers from asymmetric, bilateral hearing loss.
|Sequence Similarities:||Belongs to the SCF family.|
|Post-Translational Modification:||A soluble form (sKITLG) is produced by proteolytic processing of isoform 1 in the extracellular domain.|
|Cellular Location:||Cell membrane.|