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Anti-SDC1 Antibody

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ABclonal
A1235
Details
Description: Rabbit polyclonal antibody to SDC1.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P18827
Gene ID: 6382
Immunogen: Recombinant protein of human SDC1
Protein Length: 310
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: SDC1; CD138; SDC; SYND1; syndecan
Purification: Affinity purification
Background: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200

Target (Information from UniProt)
Function: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Sequence Similarities: Belongs to the syndecan proteoglycan family.
Post-Translational Modification: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Cellular Location: Membrane. Secreted. Secreted > Exosome.

Shedding of the ectodomain produces a soluble form.

Images
Western Blot - Anti-SDC1 Antibody from ABclonal (A1235) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using SDC1 antibody.
Immunohistochemistry - Anti-SDC1 Antibody from ABclonal (A1235) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human kidney cancer using SDC1 antibody at dilution of 1:200 (400x lens).

Product Code - A1235
Size Price Quantity
50µl £148
100µl £243
200µl £372

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