|Description:||Rabbit polyclonal antibody to SDC1.|
|Immunogen:||Recombinant protein of human SDC1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonyms:||SDC1; CD138; SDC; SYND1; syndecan|
|Background:||The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:200|
Target (Information from UniProt)
|Function:||Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).|
|Sequence Similarities:||Belongs to the syndecan proteoglycan family.|
|Post-Translational Modification:||Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.|
|Cellular Location:||Membrane. Secreted. Secreted > Exosome.
Shedding of the ectodomain produces a soluble form.
Western blot analysis of extracts of various cell lines, using SDC1 antibody.
Immunohistochemistry of paraffin-embedded human kidney cancer using SDC1 antibody at dilution of 1:200 (400x lens).