|Description:||Rabbit polyclonal antibody to GYPC.|
|Immunogen:||A synthetic peptide of human GYPC|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Synonyms:||GYPC; CD236; CD236R; GE; GPC; GYPD; MGC117309; MGC126191; MGC126192|
|Background:||Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:2000, IF 1:50 - 1:200|
Target (Information from UniProt)
|Function:||This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.|
|Tissue Specificity:||Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.|
|Sequence Similarities:||Belongs to the glycophorin-C family.|
|Post-Translational Modification:||O-glycosylated with core 1 or possibly core 8 glycans.|
|Cellular Location:||Cell membrane.
Linked to the membrane via band 4.1.
Western blot analysis of extracts of various cell lines, using GYPC antibody.
Immunofluorescence analysis of MCF7 cell using GYPC antibody. Blue: DAPI for nuclear staining.