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Anti-GYPC Antibody

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ABclonal
A1232
Details
Description: Rabbit polyclonal antibody to GYPC.
Category: Primary Antibodies
Applications: WB, IF
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P04921
Gene ID: 2995
Immunogen: A synthetic peptide of human GYPC
Protein Length: 128
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: GYPC; CD236; CD236R; GE; GPC; GYPD; MGC117309; MGC126191; MGC126192
Purification: Affinity purification
Background: Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:200

Target (Information from UniProt)
Function: This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.
Tissue Specificity: Glycophorin-C is expressed in erythrocytes. Glycophorin-D and IsoGPC are ubiquitously expressed.
Sequence Similarities: Belongs to the glycophorin-C family.
Post-Translational Modification: O-glycosylated with core 1 or possibly core 8 glycans.
Cellular Location: Cell membrane.

Linked to the membrane via band 4.1.

Images
Western Blot - Anti-GYPC Antibody from ABclonal (A1232) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using GYPC antibody.
Immunofluorescence - Anti-GYPC Antibody from ABclonal (A1232) - Antibody Supply Service
Immunofluorescence analysis of MCF7 cell using GYPC antibody. Blue: DAPI for nuclear staining.

Product Code - A1232
Size Price Quantity
50µl £148
100µl £243
200µl £372

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