|Description:||Rabbit polyclonal antibody to DEFB121.|
|Immunogen:||Recombinant protein of human DEFB121|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Background:||∫-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ∫-defensins are developmentally regulated. The family of ∫-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ∫-defensins also are involved in sperm maturation and capacitation. ∫-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ∫-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ∫-defensins, it does not appear to be regulated by androgens.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:100|
Target (Information from UniProt)
|Function:||Has antibacterial activity.|
|Tissue Specificity:||Abundant expression in the male reproductive tract only.|
|Sequence Similarities:||Belongs to the beta-defensin family.|
Western blot analysis of extracts from HepG2 cell, using DEFB121 antibody.
Immunohistochemistry of paraffin-embedded human prostate using DEFB121 antibody at dilution of 1:100 (40x lens).