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Anti-DEFB121 Antibody

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ABclonal
A1208
Details
Description: Rabbit polyclonal antibody to DEFB121.
Category: Primary Antibodies
Applications: WB, IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q5J5C9
Gene ID: 245934
Immunogen: Recombinant protein of human DEFB121
Protein Length: 76
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: DEFB121; ESC42RELC
Purification: Affinity purification
Background: ∫-defensins (also designated BDs, or hBDs in human) are small cationic peptides with broad-spectrum antimicrobial activity against a variety of enveloped viruses, fungi and bacteria. Produced in mucosal epithelia and neutrophils of several species, ∫-defensins are developmentally regulated. The family of ∫-defensin proteins share a common defensin-motif that is characterized by multiple cysteine residues and a highly conserved tertiary structure. Besides playing a significant role in host immune defense, many ∫-defensins also are involved in sperm maturation and capacitation. ∫-defensin 121 is a 76 amino acid secreted protein that most likely contains a signal peptide sequence that requires cleavage by proteolytic enzymes in order to become biologically active. While expressed at low levels in testis, ∫-defensin 121 is abundantly expressed in epididymal caput and corpus and, unlike other ∫-defensins, it does not appear to be regulated by androgens.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100

Target (Information from UniProt)
Function: Has antibacterial activity.
Tissue Specificity: Abundant expression in the male reproductive tract only.
Sequence Similarities: Belongs to the beta-defensin family.
Cellular Location: Secreted.

Images
Western Blot - Anti-DEFB121 Antibody from ABclonal (A1208) - Antibody Supply Service
Western blot analysis of extracts from HepG2 cell, using DEFB121 antibody.
Immunohistochemistry - Anti-DEFB121 Antibody from ABclonal (A1208) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human prostate using DEFB121 antibody at dilution of 1:100 (40x lens).

Product Code - A1208
Size Price Quantity
50µl £148
100µl £243
200µl £372

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