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Anti-Interleukin 31 Antibody

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ABclonal
A11476
Details
Description: Mouse monoclonal antibody to Interleukin 31.
Category: Primary Antibodies
Applications: WB
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: Q6EBC2
Gene ID: 386653
Immunogen: Recombinant protein of human IL31
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: IL-31
Purification: Affinity purification
Background: IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR (PubMed:15184896). May function in skin immunity (PubMed:15184896). Enhances myeloid progenitor cell survival in vitro (By similarity). Induces RETNLA and serum amyloid A protein expression in macrophages (By similarity).
Tissue Specificity: Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
Cellular Location: Secreted.

Images
Western Blot - Anti-Interleukin 31 Antibody from ABclonal (A11476) - Antibody Supply Service
Western blot analysis of extracts of IL31 cells, using IL31 antibody.

Product Code - A11476
Size Price Quantity
100µl £307
200µl £452

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