|Description:||Mouse monoclonal antibody to CCDC111.|
|Dilutions:||IHC 1:50 - 1:100, IF 1:50 - 1:100|
|Immunogen:||Recombinant protein of human PRIMPOL|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH.|
|Involvement in Disease:||Myopia 22, autosomal dominant: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far.|
|Sequence Similarities:||Belongs to the eukaryotic-type primase small subunit family.|
|Cellular Location:||Nucleus. Mitochondrion matrix.
Present in the nucleus, but a larger fraction is localized inside mitochondria. Associates with nuclear chromatin during the G1 and S phases of unperturbed cell cycles.
Coiled coil domain containing 111 Antibody
Coiled-coil domain-containing protein 111 Antibody
DNA-directed primase/polymerase protein Antibody
Primase and polymerase (DNA directed) Antibody