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Anti-MLKL Antibody

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Name: Anti-MLKL Antibody
Description: Rabbit monoclonal antibody to MLKL.
Applications: WB, IHC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200
Reactivity: Human
Immunogen: Recombinant protein of human MLKL
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Sequence Similarities: Belongs to the protein kinase superfamily.
Post-Translational Modification: Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane.
Cellular Location: Cytoplasm. Cell membrane.

Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
UniProt: Q8NB16
Gene ID: 197259
Synonyms: 9130019I15Rik Antibody
FLJ34389 Antibody
hMLKL Antibody
Mixed lineage kinase domain like Antibody
Mixed lineage kinase domain like protein Antibody
Mixed lineage kinase domain-like protein Antibody
MLKL (phospho S345) Antibody
MLKL (phospho S358) Antibody

Western Blot - Anti-MLKL Antibody from ABclonal (A11458) - Antibody Supply Service
Western blot analysis of extracts of various cells, using MLKL antibody.
Immunohistochemistry - Anti-MLKL Antibody from ABclonal (A11458) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human tonsil using MLKL antibody at dilution of 1:100 (40x lens).

Product Code - A11458
Size Price Quantity
100µl £372
200µl £565

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