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Anti-MERTK Antibody

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ABclonal
A11341
Overview
Name: Anti-MERTK Antibody
Description: Rabbit monoclonal antibody to MERTK.
Applications: WB, IHC, IP
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IP 1:20 - 1:50
Reactivity: Human
Immunogen: Recombinant protein of human MERTK
Host: Rabbit
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Tissue Specificity: Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.
Involvement in Disease: Retinitis pigmentosa 38: A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Post-Translational Modification: Autophosphorylated on Tyr-749, Tyr-753 and Tyr-754 in the activation loop allowing full activity. Autophosphorylated on Tyr-872 leading to recruitment of downstream partners of the signaling cascade such as PLCG2 (By similarity).
Cellular Location: Membrane.
UniProt: Q12866
Gene ID: 10461
Synonyms: AI323366 Antibody
Brt Antibody
Bruton agammaglobulinemia tyrosine kinase Antibody
BYK Antibody
c MER Antibody
c mer proto oncogene tyrosine kinase Antibody
c-mer Antibody
c-mer proto-oncogene tyrosine kinase Antibody
cMER Antibody
cmer protooncogene tyrosine kinase Antibody
Dtk Antibody
Etk 2 Antibody
Eyk Antibody
FLJ16467 Antibody
Mer Antibody
MER + SKY Antibody
MER receptor tyrosine kinase Antibody
MERK Antibody
MERPEN Antibody
MERTK (phospho Y681 + Y749) Antibody
MERTK (phospho Y749 + Y753 + Y754) Antibody
MERTK c-mer proto-oncogene tyrosine kinase Antibody
MERTK_HUMAN Antibody
MGC133349 Antibody
nmf12 Antibody
Nyk Antibody
OTTMUSP00000017810 Antibody
Proto oncogene tyrosine protein kinase MER Antibody
Proto oncogene tyrosine protein kinase MER precursor Antibody
Proto-oncogene c-Mer Antibody
rdy Antibody
Receptor tyrosine kinase Antibody
Receptor tyrosine kinase MerTK Antibody
Receptor tyrosine tinase gene probably the gene for Rdy Antibody
Retinal dystrophy Antibody
RP23-30M20.1 Antibody
RP23-356L21.1 Antibody
RP38 Antibody
RSE Antibody
Sky Antibody
STK kinase Antibody
Tif Antibody
TYRO3 Antibody
TYRO3 protein tyrosine kinase Antibody
TYRO3 protein tyrosine kinase 3 Antibody
Tyrosine protein kinase byk Antibody
Tyrosine protein kinase DTK Antibody
Tyrosine protein kinase RSE Antibody
Tyrosine protein kinase SKY Antibody
Tyrosine-protein kinase Mer Antibody

Images
Western Blot - Anti-MERTK Antibody from ABclonal (A11341) - Antibody Supply Service
Western blot analysis of extracts of 293T cells, using MERTK antibody.
Immunohistochemistry - Anti-MERTK Antibody from ABclonal (A11341) - Antibody Supply Service
Immunohistochemistry of paraffin-embedded human tonsil using MERTK antibody at dilution of 1:100 (40x lens).

Product Code - A11341
Size Price Quantity
100µl £372
200µl £565

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