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Anti-VCAM1 Antibody

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ABclonal
A11239
Details
Description: Mouse monoclonal antibody to VCAM1.
Category: Primary Antibodies
Applications: WB, IHC, IF, IP, FC
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: P19320
Gene ID: 7412
Immunogen: Recombinant protein of human VCAM1
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: CD106; INCAM-100
Purification: Affinity purification
Background: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100, IF 1:50 - 1:100, IP 1:20 - 1:50, FC 1:20 - 1:50

Target (Information from UniProt)
Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Tissue Specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Post-Translational Modification: Sialoglycoprotein.
Cellular Location: Membrane.

Product Code - A11239
Size Price Quantity
100µl £307
200µl £452

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