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Anti-Transthyretin Antibody

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Name: Anti-Transthyretin Antibody
Description: Mouse monoclonal antibody to Transthyretin.
Applications: WB, IF
Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human TTR
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Tissue Specificity: Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Involvement in Disease: Amyloidosis, transthyretin-related: A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor.

Hyperthyroxinemia, dystransthyretinemic: A condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities.

Carpal tunnel syndrome 1: A condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis.
Sequence Similarities: Belongs to the transthyretin family.
Post-Translational Modification: Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.
Cellular Location: Secreted. Cytoplasm.
UniProt: P02766
Gene ID: 7276
Synonyms: Amyloid polyneuropathy Antibody
Amyloidosis I Antibody
ATTR Antibody
Carpal tunnel syndrome 1 Antibody
CTS Antibody
CTS1 Antibody
Dysprealbuminemic euthyroidal hyperthyroxinemia Antibody
Dystransthyretinemic hyperthyroxinemia Antibody
Epididymis luminal protein 111 Antibody
HEL111 Antibody
HsT2651 Antibody
PALB Antibody
Prealbumin Antibody
Prealbumin amyloidosis type I Antibody
Prealbumin Thyroxine-binding Antibody
Senile systemic amyloidosis Antibody
TBPA Antibody
Thyroxine binding prealbumin Antibody
TTR Antibody
TTR protein Antibody

Product Code - A11221
Size Price Quantity
100µl £307
200µl £452

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