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Anti-Mast Cell Tryptase Antibody

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Name: Anti-Mast Cell Tryptase Antibody
Description: Mouse monoclonal antibody to Mast Cell Tryptase.
Applications: WB, IF, IP
Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:100, IP 1:20 - 1:50
Reactivity: Human
Immunogen: Recombinant protein of human TPSAB1
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315).
Tissue Specificity: Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level).
Sequence Similarities: Belongs to the peptidase S1 family. Tryptase subfamily.
Cellular Location: Secreted.

Released from the secretory granules upon mast cell activation.
UniProt: Q15661
Gene ID: 7177
Synonyms: alpha II Antibody
gamma I Antibody
gamma II Antibody
lung tryptase Antibody
Mast cell alpha II tryptase Antibody
Mast cell beta I tryptase Antibody
Mast cell protease 7 Antibody
mast cell protease II Antibody
MCP 7 Antibody
pituitary tryptase Antibody
PRSS31 Antibody
Serine protease 31 Antibody
skin tryptase Antibody
TMT Antibody
TPS 1 Antibody
TPS1 Antibody
TPS2 Antibody
TPSAB1 Antibody
TPSAB1 protein Antibody
TPSB1 Antibody
TPSG1 Antibody
Transmembrane tryptase Antibody
trpA Antibody
TRYG1_HUMAN Antibody
Tryptase 1 Antibody
Tryptase alpha 1 Antibody
tryptase alpha I included Antibody
Tryptase alpha II Antibody
tryptase alpha II included Antibody
tryptase alpha included Antibody
tryptase alpha/beta 1 Antibody
Tryptase beta 1 Antibody
tryptase beta I included Antibody
tryptase gamma Antibody
Tryptase gamma (EC:3.4.21.-) Antibody
tryptase gamma 1 Antibody
Tryptase gamma heavy chain Antibody
tryptase gamma I Antibody
tryptase gamma II Antibody
Tryptase gamma light chain Antibody
Tryptase I Antibody
tryptase I included Antibody
Tryptase III Antibody
Tryptase skin Antibody

Product Code - A11218
Size Price Quantity
100µl £307
200µl £452

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