|Description:||Mouse monoclonal antibody to TNNT2.|
|Applications:||WB, IHC, IF, FC|
|Dilutions:||WB 1:500 - 1:2000, IHC 1:50 - 1:100, IF 1:50 - 1:100, FC 1:20 - 1:50|
|Immunogen:||A synthetic peptide of human TNNT2|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
|Tissue Specificity:||Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart.|
|Involvement in Disease:||Cardiomyopathy, familial hypertrophic 2: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Cardiomyopathy, dilated 1D: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial restrictive 3: A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function.
|Sequence Similarities:||Belongs to the troponin T family.|
|Post-Translational Modification:||Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity.|
|Synonyms:||Cardiac muscle troponin T Antibody
Cardiac Troponin T Antibody
Cardiomyopathy dilated 1D (autosomal dominant) Antibody
Cardiomyopathy hypertrophic 2 Antibody
TNNT 2 Antibody
Troponin T cardiac muscle Antibody
Troponin T type 1 Antibody
Troponin T type 1 (skeletal, slow) Antibody
Troponin T type 2 Antibody
Troponin T type 2 (cardiac) Antibody
Troponin T type 2 cardiac Antibody
Troponin T type 3 Antibody
Troponin T type 3 (skeletal, fast) Antibody
Troponin T, cardiac muscle Antibody
Troponin T1 + T2 + T3 Antibody
Troponin T2 cardiac Antibody
Western blot analysis of extracts of mouse heart cells, using TNNT2 antibody.