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Anti-CD11b Antibody

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ABclonal
A11057
Details
Description: Mouse monoclonal antibody to CD11b.
Category: Primary Antibodies
Applications: IHC, IF, FC
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: P11215
Gene ID: 3684
Immunogen: Recombinant protein of human ITGAM
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
Purification: Affinity purification
Background: This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: IHC 1:50 - 1:100, IF 1:50 - 1:100, FC 1:20 - 1:50

Target (Information from UniProt)
Function: Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Tissue Specificity: Predominantly expressed in monocytes and granulocytes.
Involvement in Disease: Systemic lupus erythematosus 6: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Sequence Similarities: Belongs to the integrin alpha chain family.
Cellular Location: Membrane.

Product Code - A11057
Size Price Quantity
100µl £307
200µl £452

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