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Anti-Insulin Antibody

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Name: Anti-Insulin Antibody
Description: Mouse monoclonal antibody to Insulin.
Applications: IHC, IF, IP
Dilutions: IHC 1:50 - 1:100, IF 1:50 - 1:100, IP 1:20 - 1:50
Reactivity: Human
Immunogen: Recombinant protein of human INS
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
Involvement in Disease: Hyperproinsulinemia: An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material.

Diabetes mellitus, insulin-dependent, 2: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Diabetes mellitus, permanent neonatal: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy.

Maturity-onset diabetes of the young 10: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
Sequence Similarities: Belongs to the insulin family.
Cellular Location: Secreted.
UniProt: P01308
Gene ID: 3630
Synonyms: IDDM Antibody
IDDM1 Antibody
IDDM2 Antibody
ILPR Antibody
ins Antibody
Insulin + Proinsulin Antibody
Insulin A chain Antibody
Insulin B chain Antibody
INS_HUMAN Antibody
IRDN Antibody
MODY10 Antibody
Preproinsulin Antibody
Proinsulin Antibody
Proinsulin precursor Antibody

Product Code - A11054
Size Price Quantity
100µl £307
200µl £452

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