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Anti-Myeloperoxidase Antibody

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ABclonal
A11026
Details
Description: Mouse monoclonal antibody to Myeloperoxidase.
Category: Primary Antibodies
Applications: WB, IF, IP
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: P05164
Gene ID: 4353
Immunogen: Recombinant protein of human MPO
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Background: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:100, IP 1:20 - 1:50

Target (Information from UniProt)
Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Involvement in Disease: Myeloperoxidase deficiency: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.
Sequence Similarities: Belongs to the peroxidase family. XPO subfamily.
Cellular Location: Lysosome.

Images
Western Blot - Anti-Myeloperoxidase Antibody from ABclonal (A11026) - Antibody Supply Service
Western blot analysis of extracts of HL60 cells, using MPO antibody.

Product Code - A11026
Size Price Quantity
100µl £307
200µl £452

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