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Anti-LRP1 Antibody

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Name: Anti-LRP1 Antibody
Description: Mouse monoclonal antibody to LRP1.
Applications: WB, IHC, IF, FC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100, IF 1:50 - 1:100, FC 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human LRP1
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Tissue Specificity: Most abundant in liver, brain and lung.
Sequence Similarities: Belongs to the LDLR family.
Post-Translational Modification: Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
Cellular Location: Cell membrane. Membrane > Coated pit.
UniProt: Q07954
Gene ID: 4035
Synonyms: 1110036E10Rik Antibody
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Product Code - A10966
Size Price Quantity
100µl £307
200µl £452

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