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Anti-MMS19 Antibody

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Description: Rabbit polyclonal antibody to MMS19.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: Q96T76
Gene ID: 64210
Immunogen: A synthetic Peptide of human MMS19
Protein Length: 1030
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: MET18; MMS19L; hMMS19
Purification: Affinity purification
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
Tissue Specificity: Ubiquitously expressed with higher expression in testis.
Sequence Similarities: Belongs to the MET18/MMS19 family.
Cellular Location: Nucleus. Cytoplasm > Cytoskeleton > Spindle.

Western Blot - Anti-MMS19 Antibody from ABclonal (A10944) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using MMS19 antibody.

Product Code - A10944
Size Price Quantity
100µl £243
200µl £372

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