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Anti-Cytokeratin 13 Antibody

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ABclonal
A10936
Details
Description: Mouse monoclonal antibody to Cytokeratin 13.
Category: Primary Antibodies
Applications: WB, IHC, IF, IP
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: P13646
Gene ID: 3860
Immunogen: A synthetic peptide of human KRT13
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: K13; CK13; WSN2
Purification: Affinity purification
Background: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been described.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100, IF 1:50 - 1:100, IP 1:20 - 1:50

Target (Information from UniProt)
Tissue Specificity: Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.
Involvement in Disease: White sponge nevus 2: A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.
Sequence Similarities: Belongs to the intermediate filament family.
Post-Translational Modification: O-glycosylated; glycans consist of single N-acetylglucosamine residues.

Product Code - A10936
Size Price Quantity
100µl £307
200µl £452

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