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Anti-IREB2 Antibody

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ABclonal
A10925
Details
Description: Mouse monoclonal antibody to IREB2.
Category: Primary Antibodies
Applications: WB, IHC, IF, IP
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: P48200
Gene ID: 3658
Immunogen: Recombinant protein of human IREB2
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: ACO3; IRP2; IRP2AD
Purification: Affinity purification
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100, IF 1:50 - 1:100, IP 1:20 - 1:50

Target (Information from UniProt)
Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Sequence Similarities: Belongs to the aconitase/IPM isomerase family.
Post-Translational Modification: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.
Cellular Location: Cytoplasm.

Images
Western Blot - Anti-IREB2 Antibody from ABclonal (A10925) - Antibody Supply Service
Western blot analysis of extracts of Jurkat cells, using IREB2 antibody.

Product Code - A10925
Size Price Quantity
100µl £307
200µl £452

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