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Anti-IREB2 Antibody

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ABclonal
A10925
Overview
Name: Anti-IREB2 Antibody
Description: Mouse monoclonal antibody to IREB2.
Applications: WB, IHC, IF, IP
Dilutions: WB 1:500 - 1:1000, IHC 1:50 - 1:100, IF 1:50 - 1:100, IP 1:20 - 1:50
Reactivity: Human
Immunogen: Recombinant protein of human IREB2
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
Sequence Similarities: Belongs to the aconitase/IPM isomerase family.
Post-Translational Modification: Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.
Cellular Location: Cytoplasm.
UniProt: P48200
Gene ID: 3658
Synonyms: ACO3 Antibody
FLJ23381 Antibody
IRE BP2 Antibody
IRE-BP 2 Antibody
IREB 2 Antibody
IREB2_HUMAN Antibody
Iron regulatory protein 2 Antibody
iron responsive element binding protein 2 Antibody
Iron-responsive element-binding protein 2 Antibody
IRP 2 Antibody
IRP2 Antibody
IRP2AD Antibody
OTTHUMP00000185022 Antibody

Images
Western Blot - Anti-IREB2 Antibody from ABclonal (A10925) - Antibody Supply Service
Western blot analysis of extracts of Jurkat cells, using IREB2 antibody.

Product Code - A10925
Size Price Quantity
100µl £307
200µl £452

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