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Anti-IL-8 Antibody

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ABclonal
A10918
Details
Description: Mouse monoclonal antibody to IL-8.
Category: Primary Antibodies
Applications: WB, IF, IP
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Reactivity: Human
UniProt: P10145
Gene ID: 3576
Immunogen: Recombinant protein of human CXCL8
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
Purification: Affinity purification
Background: The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:100, IP 1:20 - 1:50

Target (Information from UniProt)
Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Sequence Similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Post-Translational Modification: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form.
Cellular Location: Secreted.

Product Code - A10918
Size Price Quantity
100µl £307
200µl £452

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