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Anti-PSMD10 Antibody

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Name: Anti-PSMD10 Antibody
Description: Rabbit polyclonal antibody to PSMD10.
Applications: WB, IHC, IF
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100, IF 1:50 - 1:100
Reactivity: Human
Immunogen: A synthetic peptide of human PSMD10
Protein Length: 226
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at 4℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.
Tissue Specificity: Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).
Cellular Location: Cytoplasm. Nucleus.
UniProt: O75832
Gene ID: 5716
Synonyms: 26S proteasome non-ATPase regulatory subunit 10 Antibody
26S proteasome regulatory subunit p28 Antibody
Ankyrin repeat protein Antibody
dJ889N15.2 Antibody
Gankyrin Antibody
Hepatocellular carcinoma-associated protein p28 II Antibody
p28 Antibody
p28(GANK) Antibody
Proteasome (prosome, macropain) 26S subunit, non ATPase, 10 Antibody
Proteasome 26S S10 Antibody
PSD10_HUMAN Antibody

Product Code - A10890
Size Price Quantity
100µl £243
200µl £372

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