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Anti-Hint1 Antibody

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ABclonal
A10885
Overview
Name: Anti-Hint1 Antibody
Description: Mouse monoclonal antibody to Hint1.
Applications: WB, IF, IP
Dilutions: WB 1:500 - 1:2000, IF 1:50 - 1:100, IP 1:20 - 1:50
Reactivity: Human
Immunogen: A synthetic peptide of human HINT1
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.
Tissue Specificity: Widely expressed.
Involvement in Disease: Neuromyotonia and axonal neuropathy, autosomal recessive: An autosomal recessive neurologic disorder characterized by onset in the first or second decade of a peripheral axonal neuropathy predominantly affecting motor more than sensory nerves. The axonal neuropathy is reminiscent of Charcot-Marie-Tooth disease type 2 and distal hereditary motor neuropathy. Individuals with NMAN also have delayed muscle relaxation and action myotonia associated with neuromyotonic discharges on needle EMG resulting from hyperexcitability of the peripheral nerves.
Sequence Similarities: Belongs to the HINT family.
Cellular Location: Cytoplasm. Nucleus.

Interaction with CDK7 leads to a more nuclear localization.
UniProt: P49773
Gene ID: 3094
Synonyms: Adenosine 5' monophosphoramidase Antibody
Adenosine 5''-monophosphoramidase Antibody
HINT 1 Antibody
HINT1_HUMAN Antibody
Histidine triad nucleotide binding protein 1 Antibody
Histidine triad nucleotide-binding protein 1 Antibody
PKCI 1 Antibody
PKCI-1 Antibody
PKCI1 Antibody
PRKCNH1 Antibody
Protein kinase C inhibitor 1 Antibody
Protein kinase C interacting protein 1 Antibody
Protein kinase C-interacting protein 1 Antibody

Images
Western Blot - Anti-Hint1 Antibody from ABclonal (A10885) - Antibody Supply Service
Western blot analysis of extracts of Jurkat cells, using HINT1 antibody.

Product Code - A10885
Size Price Quantity
100µl £307
200µl £452

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