|Description:||Mouse monoclonal antibody to Hint1.|
|Applications:||WB, IF, IP|
|Dilutions:||WB 1:500 - 1:2000, IF 1:50 - 1:100, IP 1:20 - 1:50|
|Immunogen:||A synthetic peptide of human HINT1|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
Target (Information from UniProt)
|Function:||Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.|
|Tissue Specificity:||Widely expressed.|
|Involvement in Disease:||Neuromyotonia and axonal neuropathy, autosomal recessive: An autosomal recessive neurologic disorder characterized by onset in the first or second decade of a peripheral axonal neuropathy predominantly affecting motor more than sensory nerves. The axonal neuropathy is reminiscent of Charcot-Marie-Tooth disease type 2 and distal hereditary motor neuropathy. Individuals with NMAN also have delayed muscle relaxation and action myotonia associated with neuromyotonic discharges on needle EMG resulting from hyperexcitability of the peripheral nerves.|
|Sequence Similarities:||Belongs to the HINT family.|
|Cellular Location:||Cytoplasm. Nucleus.
Interaction with CDK7 leads to a more nuclear localization.
|Synonyms:||Adenosine 5' monophosphoramidase Antibody
Adenosine 5''-monophosphoramidase Antibody
HINT 1 Antibody
Histidine triad nucleotide binding protein 1 Antibody
Histidine triad nucleotide-binding protein 1 Antibody
PKCI 1 Antibody
Protein kinase C inhibitor 1 Antibody
Protein kinase C interacting protein 1 Antibody
Protein kinase C-interacting protein 1 Antibody
Western blot analysis of extracts of Jurkat cells, using HINT1 antibody.