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Anti-IBSP Antibody

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ABclonal
A10867
Details
Description: Rabbit polyclonal antibody to IBSP.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P21815
Gene ID: 3381
Immunogen: A synthetic Peptide of human IBSP
Protein Length: 317
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Synonyms: BSP; BNSP; SP-II; BSP-II
Purification: Affinity purification
Background: The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
Storage: Store at 4℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Post-Translational Modification: N-glycosylated; glycans consist of sialylated and core-fucosylated bi-, tri- and tetraantennary chains.
Cellular Location: Secreted.

Images
Western Blot - Anti-IBSP Antibody from ABclonal (A10867) - Antibody Supply Service
Western blot analysis of extracts of LO2 cells, using IBSP antibody.

Product Code - A10867
Size Price Quantity
100µl £243
200µl £372

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