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Anti-ITIH1 Antibody

file icon Datasheet
Description: Rabbit polyclonal antibody to ITIH1.
Category: Primary Antibodies
Applications: WB
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Reactivity: Human
UniProt: P19827
Gene ID: 3697
Immunogen: Recombinant protein of human ITIH1
Protein Length: 911
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Background: This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.
Recommended Dilutions: WB 1:500 - 1:2000

Target (Information from UniProt)
Function: May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Sequence Similarities: Belongs to the ITIH family.
Post-Translational Modification: Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.
Cellular Location: Secreted.

Western Blot - Anti-ITIH1 Antibody from ABclonal (A10833) - Antibody Supply Service
Western blot analysis of extracts of various cell lines, using ITIH1 antibody.

Product Code - A10833
Size Price Quantity
50µl £148
100µl £243
200µl £372

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