|Description:||Rabbit polyclonal antibody to UPK2.|
|Immunogen:||Recombinant protein of human UPK2|
|Formulation:||PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Background:||This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.|
|Storage:||Store at -20℃. Avoid freeze / thaw cycles.|
|Recommended Dilutions:||WB 1:500 - 1:2000|
Target (Information from UniProt)
|Function:||Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).|
|Tissue Specificity:||Expressed in ureter.|
|Sequence Similarities:||Belongs to the uroplakin-2 family.|
|Cellular Location:||Cell membrane.
Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER).
Western blot analysis of extracts of B cells, using UPK2 antibody.