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Anti-CD63 Antibody

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Name: Anti-CD63 Antibody
Description: Mouse monoclonal antibody to CD63.
Applications: WB, IHC, IF, IP, FC
Dilutions: WB 1:500 - 1:2000, IHC 1:50 - 1:100, IF 1:50 - 1:100, IP 1:20 - 1:50, FC 1:20 - 1:50
Reactivity: Human
Immunogen: Recombinant protein of human CD63
Host: Mouse
Clonality: Monoclonal
Isotype: IgG
Purification: Affinity purification
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage: Store at -20℃. Avoid freeze / thaw cycles.

Target (Information from UniProt)
Function: Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Tissue Specificity: Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Sequence Similarities: Belongs to the tetraspanin (TM4SF) family.
Post-Translational Modification: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Cellular Location: Cell membrane. Lysosome membrane. Late endosome membrane. Endosome > Multivesicular body. Melanosome. Secreted > Exosome. Cell surface.

Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
UniProt: P08962
Gene ID: 967
Synonyms: Lysosomal associated membrane protein 3 Antibody
CD 63 Antibody
CD63 antigen Antibody
CD63 antigen (melanoma 1 antigen) Antibody
CD63 antigen melanoma 1 antigen Antibody
CD63 molecule Antibody
CD63_HUMAN Antibody
gp55 Antibody
Granulophysin Antibody
LAMP 3 Antibody
LAMP-3 Antibody
LAMP3 Antibody
LIMP Antibody
Lysosomal-associated membrane protein 3 Antibody
Lysosome associated membrane glycoprotein 3 Antibody
Mast cell antigen AD1 Antibody
ME491 Antibody
Melanoma 1 antigen Antibody
Melanoma associated antigen ME491 Antibody
Melanoma associated antigen MLA1 Antibody
Melanoma-associated antigen ME491 Antibody
MGC72893 Antibody
MLA 1 Antibody
MLA1 Antibody
NGA Antibody
Ocular melanoma associated antigen Antibody
Ocular melanoma-associated antigen Antibody
OMA81H Antibody
PTLGP40 Antibody
Tetraspanin 30 Antibody
Tetraspanin-30 Antibody
Tspan 30 Antibody
Tspan-30 Antibody
TSPAN30 Antibody

Product Code - A10802
Size Price Quantity
100µl £307
200µl £452

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